haass Optionen
haass Optionen
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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may Beryllium produced from its precursor hinein a physiologically häufig pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved in generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.
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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects. Christian Haass welches the first to demonstrate a physiological function for beta-secretase. He showed that this protease is critically required for the regulation of myelination. Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors. He was also the first to identify the highly complicated subunit composition of gamma-secretase. All these findings not only helped to understand several signaling pathways critically involved hinein brain development (such as myelination and cell differentiation) but also provided the basis for several current therapeutic approaches.
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Welches ich am günstigsten fand waren die Fahrstunden mit Joachim, wirklich ein toller Fahrlehrer bei dem du wirklich das Gefühl bekommst das es ihn spaß macht dir Dasjenige alles beizubringen. Wurde es ans herz legen An dieser stelle dein Fluorührerschein nach machen außerdem sowie es m…
Haass was awarded the Hector Science Award and is currently leading a major project on the clinical testing of an Alzheimer's antibody.
Schön: Ich habe leider nicht an meine Termin erscheinen und nehme ich komplett Verantwortung aber habe ich erwartet das zu minderst die Hälfte oder eine Gutschein erwartet leider habe ich meine Komplet Währungs verloren.
Christian Haass, Professor of Metabolic Biochemistry at LMU Munich and spokesperson for Webseite the DZNE Munich, is known for his groundbreaking research rein Alzheimer's disease. His work focuses on the molecular and cellular mechanisms of this disease rein order to gain fundamental insights into its development.
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